Interestingly, the correlations between A3C expression and immune cell infiltration varied across different grades of glioma (Figure 7D) Then, we continued to explore the correlations between A3C expression and immune checkpoint expression and found that in comparison to GBM, LGG exhibited elevated immune cell infiltration and increased expression of immune markers, such as PD-L1, indicating a more favorable immune response within the TME. Here, CD274 is linked to central nervous system cancer.