Given that aberrant DNA methylation is recognized for inducing alterations in gene expression that contribute to cancer progression, we found that the expression of A3s were positively correlated with that of DNA methyltransferases (DNMT1/2/3A/3B) across various cancer types, including COAD, HNSC, KIRP, KICH, KIRC, LGG, LIHC, CESC, LUAD, PAAD, STAD, LUSC, THCA, and testicular germ cell tumors (TGCT), as shown in Figure S6 (P < 0.05). This evidence concerns the gene DNMT1 and cancer.