Independent studies of the role of AID in MYC-driven lymphomagenesis in Eμ-Myc mice have produced variegated results (37, 38), which could possibly be explained because the Eμ-Myc model is a model of pre-B/immature lymphoma (19), with mature B cell lymphomas accounting for only 19% of tumors. Here, AICDA is linked to B-cell non-Hodgkin lymphoma.