Our results reveal that co-infection to HIV-1 and HHV-8 is associated with increased immune activation, as reflected by higher levels of sCD163, sCD25/IL-2R alpha, and sCD40/TNFRSF5 and angiogenesis as assessed by the high levels of FGF acidic, also we find high level of FGF acidic in HHV-8 mono-infected adults. Here, CD163 is linked to coinfection.