We demonstrated in this study that in ALWH with UVL, two soluble biomarkers of SIA (sCD25/IL-2R alpha and sCD40/TNFRSF5) were positively associated with plasma levels of growth factors (VEGF and FGF acidic) implicated in the pathogenesis of Kaposi sarcoma. The gene discussed is CD40; the disease is Kaposi's sarcoma.