No significant difference has been observed between HIV+&HHV8+ and HIV-&HHV8+ for sCD163 (P = 0.307); sCD25/IL-2R alpha (P = 0.157) and sCD40/TNFRSF5 (P = 0.7445) and between HIV+ and HHV8+ co-infection and HIV+ and HHV8- mono-infection for sCD163 (P = 0.520); sCD40/TNFRSF5 (P = 0.529). This evidence concerns the gene CD40 and infection.