NFKB1 and acquired idiopathic inflammatory myopathy: Given the likelihood that myocytes also actively contribute to the immunological processes driving myositis and are not simply targets of the immune response, defining pro-inflammatory signaling pathways within the muscle tissue itself (e.g., NF-κB activation resulting from engagement of TLR ligands as well as pro-inflammatory cytokines) will be critical in further elucidating the IIM disease process.