RNA-seq analysis of TAMs in colorectal cancer specifically revealed the splicing/activation of XBP1, which promoted the growth and metastasis of colorectal cancer, and XBP1 depletion inhibited the expression of tumor-promoting cytokines (including IL-6, vascular endothelial growth factor A [VEGFA], and IL-4) in TAMs.125. The gene discussed is VEGFA; the disease is colorectal cancer.