The present study aims to explore if MERS-CoV can use DC-SIGN as a direct receptor, in this way partially explaining the productive infection demonstrated in dendritic cells in the direct infection of the virus discussed by Chu et al., or if it can also act, as it does in SARS-CoV-1 and SARS-CoV-2, as a binding factor, as well as its possible role in viral dissemination. This evidence concerns the gene CD209 and infection.