IQCK and Alzheimer disease: Interestingly, in addition to the immune cell involvement that is often the hallmark for intralesional WM-enriched ME (ME19, 13, 8, 18), IQCK (IQ motif containing K), a novel risk factor for Alzheimer’s disease (AD) (58–61), is uniquely enriched in astrocytes (AST) and ependyma of the area (FigS7B).