Although RM has been widely studied, there are still some unknown factors, including the following aspects: some patients develop AKI, while the reason why other patients do not develop AKI is not clear; in some cases, myoglobin does not necessarily deposit in renal tubules leading to AKI even though creatine kinase levels are elevated, and the mechanism is not fully understood; further research is needed on the optimal treatment strategies and prevention methods for RM complicated with AKI. The gene discussed is MB; the disease is acute kidney injury.