GLP1R and Hyperglycemia: A review done by Nauck et al. suggests that GLP-1 RA lowers body weight by influencing the central nervous system and shares common mechanisms of action, which include enhancing insulin in response to hyperglycemia, suppressing glucagon secretion in hyperglycemia or euglycemia, slowing gastric emptying to prevent large post-meal spikes in blood sugar, and reducing calorie intake.