For GO analysis, in terms of the biological process, cellular components and molecular functions, the KIT and its co-expressed genes in ChRCC were significantly enriched in kinase binding, regulation of cellular response to stress, positive regulation of transferase activity, cellular response to hormone stimulus, positive regulation of cell death, transmembrane receptor protein tyrosine kinase signaling , gland development, protein kinase activity, epithelial cell differentiation, response to inorganic substance, and epithelial cell proliferation (Supplementary file Figure 8). This evidence concerns the gene KIT and chromophobe renal cell carcinoma.