The results showed that comorbidity (OR: 8.032, 95% CI: 3.556–18.140, P < 0.0001), the need for IMV (OR: 7.081, 95% CI: 2.250–22.282, P = 0.001), and ALB < 35 g/L (OR: 3.203, 95% CI: 1.151–8.912, P = 0.026) were independent risk factors of PO in children with SCAP. The gene discussed is ALB; the disease is syringocystadenoma papilliferum.