By using bioinformatics analysis, this study identified six feature genes, BBOX1, LOXL1, MACROH2A1, ITGBL1, FBLN5, and PPP4R1, involved in the conversion of CHB to HBV-LC, providing important information to elucidate the potential molecular mechanism of CHB progression to HBV-LC. Here, PPP4R1 is linked to laryngotracheoesophageal cleft.