Moreover, studies have demonstrated that a decrease in the expression of BBOX1 antisense RNA 1 (BBOX1-AS1) corresponds to diminished cellular viability and proliferation (Zhao et al., 2022), and low BBOX1 expression serves as a prognostic biomarker for clear cell renal cell carcinoma (RCC) (Kim et al., 2023). The gene discussed is BBOX1; the disease is clear cell renal carcinoma.