NUCLEOLIN and neoplasm: This cyclic RGD conjugate (which binds to αvβ3 integrins), when attached to AS1411 localizes to tumor cells as both αvβ3 integrins and nucleolin are over expressed on tumor cells. The complex penetrates deep tumors and delivers doxorubicin resulting in improved anti-tumor activity in a mouse model. The infrared MPA, as well as the Au nanocluster allows for tumor imaging both in vitro and in vivo.