Tanshinone IIA can reduce the expression of macrophage migration inhibitory factor (MIF) and inflammatory factors (MIF), TNF-α and interleukin (IL)-6 in the brain of rats with cerebral ischemia/reperfusion, thereby alleviating the effects of cerebral ischemia/reperfusion (Chen et al., 2012). Here, MIF is linked to Cerebral ischemia.