For example, acquired microcephaly with ASD is seen in syndromes associated with transcription deficiencies: methyl-CpG binding protein 2-MeCP2 (Rett), Ubiquitin-protein ligase-UBE3A (Angelman), L-type voltage sensitive calcium channel-VSCC (Timothy) and CREB-binding protein-CBP (Ebert and Greenberg, 2013). The gene discussed is CREBBP; the disease is Secondary microcephaly.