FBXW7 and brain disorder: AGO-bound miRNAs represent a major pool of circulating miRNAs (Arroyo et al., 2011), and measuring AGO-bound miRNAs may enhance the ability to distinguish brain disease subtypes (Raoof et al., 2017), and identify post-seizure from baseline samples in plasma from epilepsy patients (Raoof et al., 2018).