To obtain evidence that seizures and the pathophysiologic changes that accompany the development of epilepsy are associated with changes to the circulating AGO pool of miRNAs, we first sequenced Ago2-bound miRNAs from the plasma of mice following status epilepticus (SE) triggered by intraamygdala microinjection of kainic acid (Mouri et al., 2008; Brennan et al., 2020). This evidence concerns the gene AGO2 and epilepsy.