c) Glycogen synthase kinase-3(GSK-3b) inhibitors:Glycogen synthase is the rate-limiting step in glycogen synthesis and that is inactivated by GSK-3b.GSK- 3b inhibitor favors the synthesisof glycogen which is beneficial for the management of T2DM that is under pre-clinical stages [37]. Here, GSK3B is linked to type 2 diabetes mellitus.