The functional enrichment analysis showed that genes such as AGPAT2, AKR1B10, AKR1B15, LDH1A1,ALDH1A3, ALDH2, ALDH3A1, ALDH7A1, ANGPTL4, APOA1, APOA4, APOB, APOBEC1, APOC1, APOC3, APOE, APOL4, CYP27A1, CYP2B6, CYP2B7P, CYP2C18,CYP2C19, CYP2C9, CYP2J2, CYP2S1, CYP2U1-AS1, DGAT1, DGKG, FABP1, GK, LPA, MGAT3, MGAT3-AS1, MGLL, PCSK9, PLPP1, PLSCR4, SOAT2, SORT1,TKFC were found in obesity related pathways. The gene discussed is APOE; the disease is obesity due to melanocortin 4 receptor deficiency.