According to Figure 2C and Supplementary Table S6, XBCQD in the treatment of monkeypox virus could be mainly related to Hepatitis B (Supplementary Figure S3), AGE-RAGE signal pathway of diabetes complications, Breast cancer, Proteoglycans in cancer, Human cytomegalovirus infection, MAPK signaling pathway, Estrogen signaling pathway, Epstein–Barr virus infection, Human immunodeficiency virus 1 infection and Chemical carcinogenesis-receptor activation. The gene discussed is RENBP; the disease is breast carcinoma.