We also found that XBCQD in the treatment of monkeypox virus could be mainly related to Hepatitis B, AGE-RAGE signal pathway of diabetes complications, Breast cancer, Proteoglycans in cancer, Human cytomegalovirus infection, MAPK signaling pathway, Estrogen signaling pathway, Epstein–Barr virus infection, Human immunodeficiency virus 1 infection and Chemical carcinogenesis-receptor activation. Here, RENBP is linked to diabetes mellitus.