In contrast to our previous results, the expression levels of anti-apoptotic Bcl2, PARP 1, and miRNA-183 were significantly the highest transcriptional level in untreated cancer cells, while the cells treated with Car-NIO, Mel-NIO, and olaparib revealed significant downregulation in Bcl2, PARP 1, and miRNA-183 in MCF-7 and MDA-MB-231 cells in comparison with the untreated cancer cells. The gene discussed is BCL2; the disease is cancer.