HMGB1 and neoplasm: ICD reveals that when tumor cells die, they release damage-associated molecular patterns (DAMPs), which in turn activate reactive immune cells, assisting the body’s immune system in recognizing and eliminating remaining cancer cells, such as ATP and high mobility group box 1 (HMGB1), as well as the surface exposure of calreticulin and heat shock protein 90 (HSP90) (Krysko et al., 2012; Ahmed and Tait, 2020).