For example, NR4A1 is elevated by stressors and inflammatory agents and levels are increased in many solid tumors, fibrosis, some cardiovascular, neuronal and metabolic diseases (Pearen and Muscat, 2010; Kurakula et al., 2014; Zhang et al., 2018; Chen et al., 2020). The gene discussed is NR4A1; the disease is metabolic disease.