Studies in this laboratory have characterized the inverse agonist activities of bis-indole derived NR4A1 ligands in solid tumor-derived cancers and their beneficial effects in neuronal disease, endometriosis, and glucose uptake into muscle cells has also been reported (Lee et al., 2014a; Lee et al., 2014b; Hammond et al., 2015; Hedrick et al., 2015; Lacey et al., 2016; Mohankumar et al., 2018; Mohankumar et al., 2019; Chatterjee et al., 2020; Mohankumar et al., 2020; Shrestha et al., 2020; Karki et al., 2021; Safe et al., 2021; Safe and Karki, 2021; Shrestha et al., 2021). This evidence concerns the gene NR4A1 and endometriosis.