Several other natural products that act as anticancer agents including cytosporone B, celastrol, resveratrol and some alkaloids have also been identified as NR4A1 ligands and this will help facilitate their repurposing for treating diseases such as cancer and other inflammatory diseases in patients that highly express this receptor (Liu et al., 2010; Hu et al., 2017; Safe et al., 2021; Shrestha et al., 2021; Zhang et al., 2022). The gene discussed is NR4A1; the disease is cancer.