F8 and hemophilia A: To establish translational potential, we further tested a clinically relevant murine model of hemophilia A [factor VIII (FVIII)-deficient, FVIIInull] and found that presensitization with dPLT significantly attenuated anti-FVIII inhibitory antibody (inhibitor) generation in FVIIInull mice following recombinant human FVIII (rhFVIII) transfusion.