RHO and hyperlipidemia: As a potential candidate for the treatment of hyperlipidemia, we still need to address the following questions before using rhubarb for clinical use: (1) The use of rhubarb as a Chinese herbal medicine will inevitably be disturbed by external factors, such as the boiling method, time, and container, and whether this will affect the lipid-lowering activity and solubility of important components, such as rhodopsin and rhubarb acid.