Hao et al. reported that in AD mice, phosphorylated GluA1 ameliorates spatial memory impairment, as assessed by the MWM task [37], and Xue et al. also reported that amphetamine increases S845, but not S831, phosphorylation, in the striatum and medial prefrontal cortex of rats [45]. This evidence concerns the gene GRIA1 and memory impairment.