ABCG2 and systemic lupus erythematosus: Compared to 15 m, the significantly up-regulated pathways at adult were primarily related to antifolate resistance, ABC transporters, bile secretion, purine metabolism and cAMP signaling pathway, and the down-regulated pathways were engaged mainly in such immune processes as pertussis, systemic lupus erythematosus, and complement and coagulation cascades (Supplementary Table S6).