Compared to 15 m, the significantly up-regulated pathways at adult were primarily related to antifolate resistance, ABC transporters, bile secretion, purine metabolism and cAMP signaling pathway, and the down-regulated pathways were engaged mainly in such immune processes as pertussis, systemic lupus erythematosus, and complement and coagulation cascades (Supplementary Table S6). The gene discussed is ABCG2; the disease is pertussis.