Consistent with myeloid-bias in TGFβ role, loss of function of TGFβ signal is also reported in acute T cell lymphoblastic leukaemia (T-ALL), suggesting TGFβ-deficient haematopoietic cells shift to lymphoid lineage (Wolfraim et al., 2004). Here, TGFB1 is linked to T-cell acute lymphoblastic leukemia.