Various mechanisms of carcinogenesis have been suggested, as patients with HPGL/PCC have been found to harbor germline mutations in SDHB, SDHC, and SDHD (Eniafe and Jiang, 2021; Takács-Vellai et al., 2021). The gene discussed is SDHB; the disease is adrenal gland pheochromocytoma.