Taken together, these findings highlight a more complex role of MCP-1 in inflammatory processes regulation and suggest the necessity for a proper MCP-1 balance in the course of metabolic disorders such as EMS, in which MSI-1436 might be considered for the normalization of MCP-1 levels, as suggested by our obtained data that showed the positive relation between PTP1B inhibition and MCP-1 expression level. Here, PTPN1 is linked to metabolic disease.