A strong expression of PTP1B-associated fibrogenesis mediators including JAK1, JAK2, and STAT-3 (Figure 3(d)) that have been all demonstrated to promote liver fibrosis when activated through increased PTP1B activity, as well as the multicomponent nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) enzyme complexes NOX-1 and NOX-4, which are strongly associated with HSC activation has been detected in EMS untreated liver explants by opposition to the healthy control group (p < 0.001). The gene discussed is NOX4; the disease is Hepatic fibrosis.