Indeed, obtained data evidenced a significant upregulation of TGF-β, a master activator of liver fibrosis and downstream effectors ACVR2A and VEGF, which promote hepatic stellate cell expansion and differentiation (p < 0.001), Therewith, increased protein levels of VEGF (Figure 3(b)) were similarly observed, confirming the initiation and progression of the fibrotic process in EMS livers. This evidence concerns the gene ACVR2A and Hepatic fibrosis.