miR-1224-5p, for example, can directly target tensin 4 (TNS4) gene, decrease the levels of tensin 4 protein, and thereby inactivate the EGFR-EFNA1/EPHA2-VEGFA signaling pathway, all of which lead to the suppression of proliferation, migration, and invasion of ESCC cells [41]. This evidence concerns the gene TNS4 and esophageal squamous cell carcinoma.