It is also possible that NRF3 mRNA is insufficiently translated in cancer cells or that the protein gets destabilized during tumor progression, e.g. as a consequence of hypoxia‐induced ubiquitination and proteasomal degradation as previously shown for other tumor suppressor proteins, e.g. “deleted in breast cancer 1” (DBC1; Liu et al, 2022). Here, NFE2L3 is linked to neoplasm.