In searching for HIF2α‐regulated genes that may be directly implicated in blocking AML differentiation, we focused on Runx2 and BCL11A, which reportedly interfere with the expression of myeloid differentiation genes in AML via transcriptional repression or recruitment of co‐repressor complexes (Kuo et al, 2009; Sunami et al, 2022). This evidence concerns the gene EPAS1 and acute myeloid leukemia.