HIF2α‐regulated genes comprehend known inducers of AML pathogenesis and proliferation (FLT3, CDK6, BCL11A, and RUNX2) (Gilliland & Griffin, 2002; Kuo et al, 2009; Scheicher et al, 2015; Sunami et al, 2022) and epigenetic regulators involved in cell fate determination and differentiation via heterochromatin formation (TRIM28 and UHRF1; Czerwińska et al, 2017; Oleksiewicz et al, 2017; Zhao et al, 2017; Kim et al, 2018; Fig 2D). The gene discussed is EPAS1; the disease is acute myeloid leukemia.