Intriguingly, for the first time, we observed that specific silencing of HIF2α promotes AML differentiation, as measured by surface expression of the myeloid differentiation marker CD11b (Fig 1C, Appendix Fig S1) and morphological changes of maturing myeloid cells such as nuclear multilobulation and reduced nucleus/cytoplasm ratio (Fig 1D). Here, EPAS1 is linked to acute myeloid leukemia.