PANX1 and early-onset autosomal dominant Alzheimer disease: To investigate potential links between PANX1 and neurological conditions exhibiting dendritic spine pathology, we compared cellular localizations and biological functions of the synaptic PANX1 interactome with synaptic-enriched susceptibility genes for ASD, schizophrenia, Parkinson’s disease, and Alzheimer’s disease identified by GWASs.