PANX1 and neurodegenerative disease: While the research on PANX1 involvement in neurological conditions has primarily focused on neurodegenerative diseases, it is perhaps not surprising that the PANX1 interactome is linked to neurodevelopmental disorder molecular players, given expanding evidence for overlap between molecular mechanisms underlying neurodevelopmental disorders and neurodegenerative diseases, particularly at the synapse and the role for PANX1 in regulation of synapse development and plasticity [19–24,75].