ACTR3 and nervous system disorder: Despite the strong representation of well-established and important synaptic genes associated with neurological conditions in the PANX1 set (refer to Table 3, e.g. Dpysl2, Actr3, Hip1, several Rabs etc.), when we restricted our disease-associated analysis to “GO synaptic” genes, we only identified the vesicular trafficking regulator NSF as the sole common gene shared by PANX1 and a neurological disease susceptibility gene set (specifically for Parkinson’s disease).