PANX1 and Parkinson disease: Given that studies in Drosophila have shown that expression of a dominant-negative form of Nsf2 leads to disrupted neuromuscular junction and synaptic structural development [114,115] and that this is linked to actin-cytoskeleton regulation [116], this finding suggests that investigating the NSF-PANX1 interaction could be of key interest in terms of exploring a putative role for PANX1 in synaptic dysfunction in Parkinson’s disease [117].