PANTHER enrichment analysis of the 483 Mus musculus PANX1-interacting proteins (unique UniProt accession numbers) revealed enrichment for six PANTHER pathways, namely the ubiquitin proteasome pathway (P00060, p-value = 3.65E–04), Parkinson’s disease (P00049, p-value = 1.05E–03), integrin signaling pathway (P00034, p-value = 1.61E–03), nicotinic acetylcholine receptor signaling pathway (P00044, p-value = 3.93E–03), inflammation mediated by chemokine and cytokine signaling pathway (P00031, p-value = 1.93E–02) and Huntington disease (P00029, p-value = 1.99E–02). Here, PANX1 is linked to juvenile Huntington disease.