First, the role of SLC7A11 and GPX4 in the occurrence of RCC was verified using the StarBase-V3.0 database to demonstrate that the expression level of SLC7A11 and GPX4 was upregulated in KIRC (KIRC, also named as CCRCC) tissues compared with the corresponding normal renal tissues (Figures 1A, 1B). Here, GPX4 is linked to nonpapillary renal cell carcinoma.