To characterize the effect of NR3C1 knockdown on the proliferation of ccRCC, we divided ACHN and 786-O cells into four groups based on whether glucocorticoids (GC) were added: control, control + GC, sh-NR3C1, and sh-NR3C1 + GC. This evidence concerns the gene NR3C1 and nonpapillary renal cell carcinoma.