By detecting different ccRCC cell lines, we confirmed that NR3C1 expression was most significantly elevated in 786-O and ACHN cells, which are considered classic cell lines of ccRCC due to their positive expression of PBRM1 [23, 24], providing a basis for selecting these two cell lines for subsequent experiments. The gene discussed is NR3C1; the disease is nonpapillary renal cell carcinoma.