Indeed, a critical aspect of the EDA2R-NIK signaling pathway is its regulation of muscle-specific ubiquitin ligases, Atrogin1 and MuRF1, which are known to play key roles in muscle atrophy.2 Interestingly, in EDA2R-KO, and Myo-NIK-KO mice, the tumor-induced upregulation of Atrogin1 and MuRF1 was significantly diminished, further underscoring the role of these signaling pathways in muscle wasting. This evidence concerns the gene EDA2R and neoplasm.