Total GSK3β was statistically significantly lower in depressed-BD (D-BD) than in UD (0.86 ± 0.22 vs 1.47 ± 0.71, p: 0.04; Fig. 3A, C) and this difference is maintained even after adjustment for age, sex, age at onset, duration of current MDE, medical and psychiatric comorbidities and HAM-D and HAM-A baseline levels. The gene discussed is GSK3B; the disease is Behcet disease.