ANXA1 and esophageal squamous cell carcinoma: In esophageal squamous-cell carcinoma (ESCC), Chen et al. employed spatial transcriptomics to characterize the progression of ESCC tumorigenesis across different stages, highlighting the gradual depletion of ANXA1 in epithelial cells along the tumorigenesis process, which in turn promotes ESCC by triggering the formation of cancer-associated fibroblasts [213].