According to a survey, cyclooxygenase-2 (COX-2) inhibitors exhibit the most remarkable response rate (80%) among drugs used to treat various diseases, while tumor chemotherapy displays the lowest response rate (25%).1 Furthermore, the response rates for various other medications varied from 50–75%, indicating that a significant proportion of patients did not benefit from these treatments.1 Secondly, the rate of ADRs caused by IVDR is not the same thing. The gene discussed is PTGS2; the disease is neoplasm.