Recently research has revealed the influence of ADT on the immune system and gut microbiota, and how this affects the progression of prostate cancer (PCa).442 ABI is a widely used drug in ADT, and research by Terrisse et al. underlined the crucial role of thymus-dependent T cells in regulating PCa progression, as CD4+ and CD8+ T cells consumption leads to a partial decrease in tumor development controlled by IVDR.443 Furthermore, the beneficial gut microbiota, e.g., A. muciniphila and Lachnospiraceae, were depleted in patients treated with ABI. Here, CD8A is linked to posterior cortical atrophy.