In addition, evidence has shown reduced Clock gene expression in the brain of drug‐resistant epilepsy patients, and that targeted deletions of the Clock gene in excitatory and parvalbumin‐expressing inhibitory neurons of transgenic mice results in decreased thresholds of pentylenetetrazol‐induced seizures, increased epileptiform discharges, and seizures arising from sleep.52 The gene discussed is PVALB; the disease is epilepsy.