SCD and hepatocellular carcinoma: By re-analysis the public transcriptional GEO datasets (accession code GSE96793, GSE9679427 and GSE12115328) of sorafenib-treated HCC tumor cells and sorafenib-resistant xenografts, an overlap of 13 genes, including SCD1, was identified as the core gene set involved in sorafenib-resistant (Supplementary Fig. 4a).