ACSL4 and hepatocellular carcinoma: By analysis of the WES and transcriptome data of this cohort, we found that in HCC patients with p53-WT status, the SCD1 expression was lower in URIlow tumors than in URIhigh tumors, while other ferroptosis-associated molecules, such as ACSL4, ALOX12, GPX4, SLC7A11, and AIFM2, were not significantly altered (Fig. 8e).