Furthermore, the high levels of Il1b, Tnfr1 and Myd88 expression detected in MCJ-deficient mice housed alone significantly decreased in cohoused MCJ-deficient mice after colitis induction, indicating that specific members of MCJ-deficient microbiota might be responsible for inducing increased pro-inflammatory cytokine production. The gene discussed is TNFRSF1A; the disease is colitis.