Prior to DSS-induced colitis, OTUs belonging to the genera Faecalibacterium (adjusted P = 0.018) and Streptococcus (adjusted P < 0.0001) were enriched in MCJ-deficient mice compared to WT, which instead exhibited increased abundance of Bifidobacterium (adjusted P = 0.029), Acidaminococcus (adjusted P = 0.013) and Candidatus Arthromitus (adjusted P = 0.029) (Fig. 6d). This evidence concerns the gene DNAJC15 and colitis.