Interestingly, except for a single case that acquired a known driver mutation in POLR2A and simple large 2q-loss, all other meningiomas (n = 9) exhibited complex rearrangements, including cases of possible chromothripsis (Fig. 2a), and a remarkable property of preserving or regaining copy neutrality for a short segment of 115 kilobases (kb, from 219,825,716 to 219,940,962, Fig. 2b). The gene discussed is POLR2A; the disease is meningioma.