IHH and meningioma: Four protein-coding genes localize to this region (FEV, CRYBA2, CFAP65 and IHH), one of which is the secreted hedgehog (Hh) pathway ligand, IHH. We found two more meningiomas that showed chromothripsis but covering only ~4 Mb of 2q arm collectively and exhibited the same property (Fig. 2a, bottom two samples).