PTCH1 and meningioma: We found that all the samples that acquired those SVs clustered with meningiomas harboring known Hh activating events (Fig. 3a, cluster 1, which we call the Hh cluster), such as a recurrent mutation SMOL412F and a damaging one in PTCH1 (ENST00000331920.6:c.1503+3A>G).