IHH and meningioma: Interestingly, we found that while IHH-activating meningiomas due to tandem duplications (n = 8, Supplementary Data 8) or simple translocations on 2q35 (n = 2, Table 1) were all found in the traditional skull base Hh niche, those due to complex rearrangements (chromothripsis or those cannot be described as a single SV type) were typically found in non-skull base or lateral middle cranial fossa (8 of 11, Supplementary Data 6; Fisher exact test P-value = 0.001).