The meningioma that was identified to acquire a focal gain at 7q36.3 using WES (MN-60924, SHH-TD in Fig. 3d) also exhibited upregulation of SHH. It is notable that among the four genes (FEV, CRYBA2, CFAP65 and IHH) where the copy numbers were preserved or gained (see above), only IHH showed a consistent upregulation of all the samples that acquired 2q35 events (Supplementary Fig. 9). The gene discussed is CRYBA2; the disease is meningioma.