Multiple genetic drivers of T-ALL, including activating mutations in NOTCH1, deletion of the CDKN2A tumor suppressor locus, and aberrant expression of transcription factors, such as T-cell acute lymphocytic leukemia 1 (TAL1) and LIM domain only 2 (LMO2), have been identified8–11. This evidence concerns the gene LMO2 and acute lymphoblastic leukemia.