Notably, survival of T-ALL cells co-cultured with monocytes or M-CSF-derived macrophages was significantly impaired in the presence of the FAK/PYK2 inhibitor PF-562271 (Fig. 8b, c), as was activation of IGF1R in T-ALL cells (Fig. 8d, e). Here, PTK2B is linked to acute lymphoblastic leukemia.