ITGB1 and acute lymphoblastic leukemia: As in LN3 T-ALL, LMO2 T-ALL cells expressed higher levels of Itgα9 and Itgβ1 transcripts relative to healthy thymocytes and higher levels of ITGα9, ITGβ1, and ITGβ2 protein relative to non-leukemic T cells from the same splenic tumor environment (Supplementary Fig. 9a, b).