To identify potential mediators of physical interactions, we carried out further transcriptional analyses between thymic T-ALL cells versus healthy thymocytes and found that the “Integrin1” pathway was preferentially enriched in T-ALL cells (Supplementary Fig. 2a, b), and ITGβ1 transcript and protein levels were elevated in T-ALL cells (Fig. 1c, d, Supplementary Fig. 2c). Here, ITGB1 is linked to acute lymphoblastic leukemia.