CD4 and colon adenocarcinoma: No significant correlation was observed between B cell infiltration level and COL1A2 expression in COAD (Fig. 9B), while increased COL1A2 expression was positively associated with the abundance of CD8+ T cells (Fig. 9C), CD4+ T cells (Fig. 9D), macrophages (Fig. 9E), dendritic cells (Fig. 9F) and neutrophils (Fig. 9G) in COAD.