Database analysis revealed that seven host genes (NEAT1, SAMD12, KDM5D, ZFY, EIF1AY, TXLNGY, and DDX3Y) of nine DEcircRNAs were also differentially expressed in blood samples of patients with glaucoma, and the trend of differential expression of circRNAs and host genes was consistent. Here, KDM5D is linked to glaucoma.