Compared to normal colon, median ARHGEF7 and CHRM3 transcript levels were higher in adenocarcinomas [21.734 vs. 18.244 per million for ARHGEF7 (p = 1.3962E-10); 2.528 vs. 1.272 for CHRM3 (p = 0.00236)] (Fig. 2a). This evidence concerns the gene CHRM3 and adenocarcinoma.