Further examples are studies showing DNA methylome [55] remodelling of patients with sepsis caused by gram-negative bacteria operates through JAK2-STAT pathway coupled with IFNγR upon autocrine/paracrine IFNγ release [56]; persisting monocyte changes in pneumonia patients involving lipid metabolism through an integrated transcriptomic and DNA methylation analysis [57]; and that LPS-treated human monocytes show reduced levels of histone H3K27ac and H3K4me1 at promoters and enhancers of phagocytic and lipid metabolism genes [36]. This evidence concerns the gene IFNG and pneumonia.