From Additional file 2: Table S1, we found Joanne L et al. presented the first proteomics analysis of exosomes derived from bladder cancer cell lines in 2010, they reported 353 high quality identifications of which 72 proteins were not found by other human exosome studies before, what’s more, authors found that basigin 5T4 and galectin-3 were confirmed positive in exosomes derived from urine of bladder cancer patients, indicating they might play important roles in bladder cancer formation [67]. The gene discussed is LGALS3; the disease is urinary bladder cancer.