CDC42 and atherosclerosis: Specifically, CDC42 mediates endothelial regeneration and vascular recovery by the p21-activated kinase 1/protein kinase B pathway to reduce atherosclerosis [14], decreases the recruitment of macrophages and controls T helper type 17/inducible regulatory T balance to inhibit systemic inflammation [13, 19], and enhances apoA-I-mediated cholesterol efflux through adenosine triphosphate-binding cassette transporter A1 to decrease blood lipids [20].