The univariable model revealed that CDC42 at D7 (high vs. low) (hazard ratio (HR): 0.188, P = 0.018) was associated with a lower TLF rate, while diabetes mellitus (yes vs. no) (HR: 4.854, P = 0.022), multivessel disease (yes vs. no) (HR: 9.469, P = 0.033), and TG (high vs. low) (HR: 10.945, P = 0.023) were linked with higher TLF rates in DCB-treated SV-CAD patients. Here, CDC42 is linked to coronary artery disorder.